Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: a simulation study based on phase III trial data

Continuing tyrosine kinase inhibitor (TKI)-mediated targeting of the BCR-ABL1 oncoprotein is the standard therapy for chronic myeloid leukemia (CML) and allows for a sustained disease control iPhone 11 in the majority of patients.While therapy cessation for patients appeared as a safe option for about half of those patients with optimal response, n

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Puberty initiates a unique stage of social learning and development prior to adulthood: Insights from studies of adolescence in wild chimpanzees

In humans, puberty initiates a period of rapid growth, change, and formative neurobehavioral development.Brain and behavior changes during this maturational window contribute to opportunities for social learning.Here we provide new insights into adolescence as a unique period of social learning and development by describing field studies of our clo

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